In an article just published in the international journal PLOS ONE, Trinity College Dublin researchers Kevin Mitchell and Jackie Dolan reported that removing gene Elfn1 in mice led to hyperactivity and comorbid seizures. In addition, amphetamines decreased their hyperactivity whereas it stimulated it in mice with this gene. This led to speculation that mutations of this gene in humans might contribute to ADHD.
According to Dr Levinson, “This study may further clarify earlier findings by Hebert and colleagues indicating that a genetic defect in mice impairing the inner-ear leads to hyperactivity, supporting my inner-ear or cerebellar-vestibular hypothesis of ADHD. It appears that both animal and neuroimaging studies in man are converging to provide us with greater clues as to the origin of this and related or comorbid epilepsy, dyslexia and other disorders.”
About Harold Levinson, M.D.
Formerly Clinical Associate Professor of Psychiatry at New York University Medical Center, Dr. Harold Levinson is currently Director of the Levinson Medical Center for Learning Disabilities in Great Neck, Long Island, New York. He is a well known neuropsychiatrist, clinical researcher and author. His “highly original” research into the cerebellar-vestibular (inner-ear) origins and treatment of dyslexia and related learning, attention-deficit/hyperactivity and anxiety or phobic disorders has evolved over the past four decades. Initially supported by Nobel Laureate Sir John Eccles and other outstanding cerebellar neurophysiologists and inner-ear scientists, Levinson’s research has more recently been independently validated worldwide by highly sophisticated neuroimaging brain studies.
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